DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS
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چکیده
منابع مشابه
Rasgrp4-dependent Arthritis and Proliferation of Fls
Michihito Kono, MD, Shinsuke Yasuda, MD, PhD, Hideyuki Koide, Takashi Kurita, MD, Yuka Shimizu, MD, Yusaku Kanetsuka, MD, Kenji Oku, MD, PhD, Toshiyuki Bohgaki, MD, PhD, Olga Amengual, MD, PhD, Tetsuya Horita, MD, PhD, Takao Koike, MD, PhD, and Tatsuya Atsumi, MD, PhD: Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Richar...
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BACKGROUND The DNA of rheumatoid arthritis synovial fibroblasts (RASF) is globally hypomethylated; this contributes to an aggressive behaviour. In an attempt to remethylate these cells, we supplemented with methyl donors. We investigated the possible interference of microRNAs (miRs). MATERIAL AND METHODS RASF were treated with L-methionine or betaine. Transcripts of de novo methyltransferases...
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ژورنال
عنوان ژورنال: Epigenomics
سال: 2015
ISSN: 1750-1911,1750-192X
DOI: 10.2217/epi.15.15